Change sequences should also provide either an air, or preferably, a water shower to ensure that personnel are thoroughly clean prior to donning sterilized PPE and entering the suite. Preference should be given to biodegradable and eco-friendly animal … Scientific discovery is dependent on the ability to formulate a process, reproduce tests, and compare results. trailer endstream endobj 147 0 obj <>/Size 97/Type/XRef>>stream If a range of species will be housed, design requirements regarding noise, vibration, temperature, humidity and lighting for all species under consideration must be met. For example, absence of respiratory pathogens such as influenza is desirable when investigating a drug's effect on lung function. Sterilization of incoming materials requires direct access to a double door autoclave or similar chemical disinfection device. All finishes must be resistant to chemical disinfectants and designed to withstand hot water hose-down procedures. 0000001336 00000 n 0000004462 00000 n The solutions they design are perfectly adapted to meet the local expectations. This includes, and truly begins, with proving that animal models forming the basis of research are as homogenous as feasible from the outset, and this has driven demand for rigorous design of SPF barrier facilities. Conversely, animals bred within open or exposed caging systems within a barrier facility do develop microflora and are not classified gnotobiotic due to their exposure to microorganisms within the room. 148 0 obj <>stream 0000005343 00000 n 0000005630 00000 n To meet animal needs, reduce animal stress and allow staff to care for animals safely and efficiently, housing should be double-compartment. Photo courtesy of HERA laboratory planners. Travel paths of materials, animals and personnel should be carefully planned to eliminate unnecessary exposure to contaminants and minimize travel distance to support functions such as loading docks. 0000100485 00000 n Nov 12, 2018 | Individually Ventilated Caging, Rodent Housing, by Rainey Hufstetler, HERA  |  Laboratory Equipment   |   11/07/2018. (4) Animal infection experiment in biosafety laboratory. Animal Pi ki NPicking N C Research Facilities 2009 Tradeline Conference Series BARRIER FACILITIES N CtNew Cost-Eff ti S l ti f Effective Solutions from a Range of Options Concurrent Forum Session Concurrent Forum Session J“J” October 19, 2009 Lloyd E.L. Fisk, AIA LEED AP Reseaesea c ac es es grch Facilities Design endstream endobj 98 0 obj <>/Outlines 8 0 R/Metadata 27 0 R/PieceInfo<>>>/Pages 26 0 R/PageLayout/OneColumn/OCProperties<>/OCGs[99 0 R]>>/StructTreeRoot 29 0 R/Type/Catalog/Lang(�� E N - U S)/LastModified(D:20081125141459)/PageLabels 24 0 R>> endobj 99 0 obj <. The Department of Laboratory Animal Resources (LAR) maintains a specific pathogen free (SPF) animal area for SPF mice. 0000064612 00000 n 0000006168 00000 n 0000064399 00000 n In order to maintain pressure differentials, Air Pressure Resistant (APR) or gasketed doors may be used at the barrier boundaries to contain decontamination gases and meet room volume testing criteria. Scientific need defines both the barrier requirements as well as the pathogen exclusion of any given colony, but the use of barrier facilities in breeding is generally based on the need to precisely control the health status of the research animals, provide genetically equivalent sample stock, optimize breeding and life span, and increase the repeatability and reproducibility for animal experiments. 0000010417 00000 n 0000006689 00000 n Barrier suites should be located within a clearly demarcated, access-controlled area inside the building. If an animal watering system is provided, it should include reverse osmosis treatment to remove potentially infectious agents. 0000059926 00000 n Image: The Joseph E. Walther Hall (Research III Building) at Indiana University School of Medicine. 0000005007 00000 n %PDF-1.4 %���� Educational facilities are multi-purpose by nature. %%EOF David Lee-Parritz, in Surgical Research, 2001. laboratory animal facilities — characteristics, design and development, 2003. of air. In design terms, circulation in an animal facility refers to the movement of animals, materials, and personnel into, out of and within the facility, and between spaces in the facility. 3{�,lv�>�i��I��6ue�^�)a�耀���P��� S�� ��"���zl2�D?�9��mH`8�8����A�]CV�o&.���>7�5�f�7E�͆ 0000070955 00000 n Similarly, the entry and exit sequences into a barrier facility are designed to prevent contaminants entering from corridors. ITS Labworks provides design & engineering solutions that cater to the laboratory, medical & commercial projects. 0000000016 00000 n Specific-pathogen free (SPF) animals were introduced into biomedical research in the early 1960s to reduce the incidence of disease into experimental design. The design should consider both the physical requirements of the barrier space as well as the operational needs of this specialized function. 0000047554 00000 n “We wanted animal shelters that invited people in and made them comfortable enough to create a relationship with a pet,” said Linda Gordon, a former liaison to the Bureau of Engineering for L.A. High containment design capitalizes on the physical isolation provided by a box-in-a-box design by providing a physical separation of the containment block inside a zone that is not bound by exterior wind and temperature conditions. Similarly, all incoming materials including food and bedding must be sterilized at the barrier boundary. Ensuring optimal design and operations strategies, in conjunction with strong biosafety practices, are keys to a successful breeding program and enable scientific discovery. 0000060175 00000 n Designing for Containment 0000087548 00000 n The initial sanitization and sterilization of a newly built animal facility for the breeding and holding of specified pathogen free (SPF) rats and mice is described. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. In some facilities, it may be appropriate to maintain dedicated “clean” PPE within the facility at the clean change side to reduce sterilization and laundering of PPE. SPF:a is an award-winning Los Angeles architecture firm specializing in the design of cultural buildings, civic works, residential developments, and creative office space. Sixty years later, SPF status has become a variable itself in biomedical research. Additional procedural spaces may be required for work associated with some species such as poultry, for incubation or hatching. At all perimeter entries for both personnel and materials, interlocked, access-controlled doors should be provided. 0 She has written and presented to a variety of audiences including I2SL, CDC and ABSA on sustainable approaches in containment facility design. Animals born via c-section and housed in closely monitored aseptic microisolator environments do not develop complex microflora and can be classified ‘germfree’ or ‘gnotobiotic,’ allowing the researcher to control exposure to relevant microorganisms relevant to their research. p. 16 3. The Laws, Regulations, and Guidelines for Animal Research in China Mainland (China), Japan, and South Korea (Korea) will be discussed in this chapter. As a one-stop systems integrator for projects, we provide planning, consultancy & project management services in addition to engineering, internal fit-out solutions & preventative maintenance programmes that cater to all aspects of the laboratory & commercial facilities. 0000064191 00000 n ���Cx����` ��g``�����4��8�8 ��W��a`��e�0 KC% 0000003291 00000 n Specific Pathogen Free (SPF) Level 1 Facilities Each facility has its own waste profile. 0000005044 00000 n 0000010673 00000 n The critical ‘reproducibility’ requirement is met by breeding animal stock that provides a consistent, quantifiable baseline for experimentation. Reduction: use of methods that enable researchers to obtain comparable levels of information from fewer animals, or to obtain Facility design Most laboratory animal facilities may include the following (Institute for Laboratory Animal Research. 0000012690 00000 n Not only does this type of separation lessen the strain on the mechanical system, but it also lessens the transmission probability between one side of the wall and the other via improperly sealed penetrations that permit possibly contaminated air, water or vermin from adjacent spaces to infiltrate the barrier facility. 0000006466 00000 n This 13,000-ft 2 facility includes specific pathogen-free transgenic animal suites, 2 surgical rooms and adjacent treatment and prep areas, conventional animal rooms, and a separate wing housing wild-caught species. A cornerstone of successful shelter design is determining the right size and type of animal housing. These facilities, sometimes referred to as specific pathogen-free (SPF) facilities, may be designed as stand-alone buildings used for production facilities or as components of larger animal research programs. Our experts design the most efficient breeding scheme to save on … Change sequences should be incorporated at the suite entry to permit personnel to change into complete SPF-dedicated personal protective equipment (PPE) including sterilized footwear, scrubs or gowning, eyewear, and any additional safety covering necessary for working with animals. Traditional containment design prevents pathogens from leaving the containment envelope by using negative pressure cascades and sealed boundaries. Some of the earliest decisions to be made in the planning process are circulation issues, both outside and inside an animal facility. This change sequence typically is an access-controlled dirty change room, which is entered from the corridor. They should be located so that exhaust air does not enter the facility or other build-ings. Universal design is a planning approach which focuses on the diversity of building users during the facility design process. The design should consider how the animals will be removed, in what quantities they will be moved and where they will be taken. Operations at the Specific-Pathogen-Free (SPF) vivarium in Australia’s Translational Research Institute (TRI) are likely indicators of trends in animal facilities across the globe. 0000008099 00000 n Designations are based on several factors, including the facility's known rodent pathogen status, sentinel rodent testing strategy, and quarantine capability/disease response plan. Categories Explained: Category 1 ABPs include: Any domestic or wild animal infected or suspected as being infected with a disease transmittable to humans or animals is classified as Category 1 ABP. These recommendations intend for all animals to be housed individually (exceptions: mothers and offspring, bonded pairs, juveniles, purpose-designed group housing). While there are significant differences in how these have been developed and implemented in each country, they are based on basic ethical principle… The animal holding rooms, where colonies are born and reared, are the most positive to the surrounding support spaces which maximizes isolation of the animals and ensures the desired health status. Depending on the breeding requirements, the barrier may be defined as the microisolator environment in which an animal is housed or as the entire suite. In barrier suites where multiple holding rooms are included, zone isolation of the separate holding rooms to permit individual decontamination of the spaces is advisable. 0000010095 00000 n 1. 0000005880 00000 n Germfree, Gnotobiotic, or SPF? A suitable breeding environment is important to have large litter sizes and shorten the timelines to produce mouse models. 0000018348 00000 n 0000035807 00000 n (3) The use of IVC in various short-term animal experiments is more in line with actual needs. The staff includes 5 full-time employees plus student labor. circulation patterns. travelling from SPF clean room (Green) to Nude/SCID room (See Procedures section 2.a.i.1 thru 7): Disinfect shoes/boots with an appropriate disinfectant when entering an SPF large animal room after a quarantine or biocontainment large animal housing room. Capped floor drains should include deep seal traps filled with chemical disinfectant. Animal transport Facility barriers SPF solutions Multimodal transport Animal care Anesthesia (injection/gas) Solutions for these common areas can be tailored to the specific laboratory objectives. DOI: 10.15406/mojt.2018.04.00100 Replacement: methods which avoid or replace the use of animals in Research. The scope of activities may include research and production of genotypes stock for medical and bioresearch use elsewhere. (1) IVC can be used for breeding production of SPF-class experimental animals. 97 52 0000013648 00000 n 0000001855 00000 n These animals “may be referred to as specific pathogen-free (SPF) to indicate that the colony from which they originated tested negative for certain pathogens and perhaps other adventitious agents that may interfere with research without causing disease. The fumigation programme was started with methyl bromide treatment directed primarily against arthropods, followed by ammonia spray to kill coccidial oocysts and concluded by three formaldehyde treatments with fog and spray against … For breeding production of SPF-class experimental animals area for SPF mice variety audiences. Opit: 20 emu Citation: Deshmukh P. animal Research and type of facilities... 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